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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 947113Generated: October 28, 2026

Tetrahydrofuran → tert-Butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylate

https://huagongshe.com/reaction/947113

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTetrahydrofuranHCID 8028—
ReactantHexaneHCID 8058—
ReactantBenzene, 1-bromo-2-(trifluoromethyl)-HCID 9806—
Reactanttert-Butyl 4-oxopiperidine-1-carboxylateHCID 735900—
ReactantButyllithiumHCID 178418339—
Producttert-Butyl 4-hydroxy-4-[2-(trifluoromethyl)phenyl]piperidine-1-carboxylateHCID 49760255—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-3dc9d92193d444da98734d00e20753f8
Source noteValidation data from https://doi.org/10.1039/C8SC04228D