Acetate → 3-Methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester

HRID 947155Notes

Reaction equation

HRID 947155 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[o:9][c:10]2[c:11]([c:12]1[CH3:13])[c:14]([O:18][S:19]([C:20]([F:21])([F:22])[F:23])(=[O:24])=[O:25])[cH:15][cH:16][cH:17]2.[CH2:34]1[CH2:35][O:36][CH2:37][CH2:38][NH:39]1.[K+:31].[K+:32].[K+:33].[O-:47][C:48]([CH3:49])=[O:50].[O-:51][C:52]([CH3:53])=[O:54].[O:40]1[CH2:41][CH2:42][O:43][CH2:44][CH2:45]1.[OH2:55].[P:26]([O-:27])([O-:28])([O-:29])=[O:30].[Pd+2:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[c:8]1[o:9][c:10]2[c:11]([c:12]1[CH3:13])[c:14]([N:39]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1)[cH:15][cH:16][cH:17]2

Participants

9

Reactant 8

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 8083MorpholineHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 865990303-Methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid tert-butyl ester

Product 1

HCID 687154533-Methyl-4-morpholin-4-yl-benzofuran-2-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-6cefa483c53d48babf854e23070ffa92
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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