Dimethyl Sulfoxide → 4-[(2-hydroxyethyl)amino]benzonitrile

HRID 947304Notes

Reaction equation

HRID 947304 reaction equation
[C:14](=[O:15])([O-:16])[O-:17].[CH3:20][S:21]([CH3:22])=[O:23].[F:1][c:2]1[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1.[K+:18].[K+:19].[NH2:10][CH2:11][CH2:12][OH:13].[OH2:24]>>[c:2]1([NH:10][CH2:11][CH2:12][OH:13])[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 700EthanolamineHCID 813Potassium Cation2×HCID 962WaterHCID 145174-FluorobenzonitrileHCID 19660Carbonate Ion

Product 1

HCID 2946154-[(2-hydroxyethyl)amino]benzonitrile

Sources & evidence

ORD record
ord-befd3003561e4404afc9c8106d7308ab
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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