2-Fluorophenyl isocyanate → 1-[2-(4-Amino-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-5-carbonyl)-pyridin-4-yl]-3-(2-fluoro-phenyl)-urea
Reaction equation
[F:1][c:2]1[c:3]([N:8]=[C:9]=[O:10])[cH:4][cH:5][cH:6][cH:7]1.[NH2:11][c:12]1[c:13]2[c:14]([n:15][cH:16][n:17]1)[n:18]([CH:30]([CH3:31])[CH3:32])[cH:19][c:20]2[C:21](=[O:22])[c:23]1[n:24][cH:25][cH:26][c:27]([NH2:29])[cH:28]1.[NH2:33][c:34]1[c:35]2[c:36]([C:37]([c:38]3[cH:39][cH:40][n:41][c:42]([NH:43][C:44]([NH:45][c:46]4[cH:47][cH:48][cH:49][cH:50][c:51]4[F:52])=[O:53])[cH:54]3)=[O:55])[cH:56][n:57]([CH:58]([CH3:59])[CH3:60])[c:61]2[n:62][cH:63][n:64]1>>[F:1][c:2]1[c:3]([NH:8][C:9](=[O:10])[NH:29][c:27]2[cH:26][cH:25][n:24][c:23]([C:21]([c:20]3[c:13]4[c:12]([NH2:11])[n:17][cH:16][n:15][c:14]4[n:18]([CH:30]([CH3:31])[CH3:32])[cH:19]3)=[O:22])[cH:28]2)[cH:4][cH:5][cH:6][cH:7]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-0647cf5badae4fe9878402c019999473
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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