反应详情

The method described in Part J of Example 365 was used to oxidize and aminate 1-(2-methylpropyl)-9-(4-propoxyphenyl)-1H-imidazo[4,5-c]quinoline (1.1 g, 3.1 mmol). The amination reaction was stirred for 36 hours. The crude product was purified by HPFC (eluting with chloroform:CMA in a gradient from 100:0 to 70:30) to provide an oil, which was stirred with acetonitrile to provide a solid. The solid was isolated by filtration and recrystallized from acetonitrile to provide 165 mg of 1-(2-methylpropyl)-9-(4-propoxyphenyl)-1H-imidazo[4,5-c]quinolin-4-amine as light tan needles, mp 181–182° C.

1. customThe amination reaction
2. customThe crude product was purified by HPFC (
3. washeluting with chloroform
4. customCMA in a gradient from 100:0 to 70:30) to provide an oil, which
5. customto provide a solid
6. customThe solid was isolated by filtration
7. customrecrystallized from acetonitrile