2-Methylbenzimidazole → 4-(5-(2-methyl-1H-benzo[d]imidazol-1-yl)-2-((3-(1,1-dioxo-thiomorpholino)azetidin-1-yl)methyl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine

HRID 947830Notes

Reaction equation

HRID 947830 reaction equation
[C:40](=[O:41])([O-:42])[O-:43].[CH3:30][c:31]1[nH:32][c:33]2[c:34]([n:35]1)[cH:36][cH:37][cH:38][cH:39]2.[Cl:1][c:2]1[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH:14]([N:16]3[CH2:17][CH2:18][S:19](=[O:22])(=[O:23])[CH2:20][CH2:21]3)[CH2:15]1)[n:10]2.[Cs+:44].[Cs+:45].[O:46]1[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1.[O:54]=[C:55]([CH:56]=[CH:57][c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1)[CH:64]=[CH:65][c:66]1[cH:67][cH:68][cH:69][cH:70][cH:71]1.[O:72]=[C:73]([CH:74]=[CH:75][c:76]1[cH:77][cH:78][cH:79][cH:80][cH:81]1)[CH:82]=[CH:83][c:84]1[cH:85][cH:86][cH:87][cH:88][cH:89]1.[O:90]=[C:91]([CH:92]=[CH:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[CH:100]=[CH:101][c:102]1[cH:103][cH:104][cH:105][cH:106][cH:107]1.[Pd:52].[Pd:53]>>[c:2]1(-[n:35]2[c:31]([CH3:30])[n:32][c:33]3[c:34]2[cH:36][cH:37][cH:38][cH:39]3)[n:3][c:4]([N:24]2[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[c:5]2[c:6]([n:7]1)[s:8][c:9]([CH2:11][N:12]1[CH2:13][CH:14]([N:16]3[CH2:17][CH2:18][S:19](=[O:22])(=[O:23])[CH2:20][CH2:21]3)[CH2:15]1)[n:10]2

Participants

8

Reactant 7

HCID 119842-MethylbenzimidazoleHCID 19660Carbonate IonHCID 23938Palladium2×HCID 312751,4-DioxaneHCID 95417Dibenzylidene acetone3×HCID 104967Cesium cation2×HCID 596058185-Chloro-2-[3-(1,1-Dioxo-1-thiomorpholin-4-yl)azetidin-1-ylmethyl]-7-morpholin-4-ylthiazolo[5,4-d]pyrimidine

Product 1

HCID 596056864-(5-(2-methyl-1H-benzo[d]imidazol-1-yl)-2-((3-(1,1-dioxo-thiomorpholino)azetidin-1-yl)methyl)thiazolo[5,4-d]pyrimidin-7-yl)morpholine

Sources & evidence

ORD record
ord-68477c5d5c194fba90304b1d434a434d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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