4-Methyl-1,3-oxazolidin-2-one → 3-[4-[4-(5-Cyclopropyl-2-pyridinyl)piperazine-1-carbonyl]-3,5-difluorophenyl]-4-methyl-1,3-oxazolidin-2-one

HRID 947903Notes

Reaction equation

HRID 947903 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:26])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH:23]4[CH2:24][CH2:25]4)[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1.[CH3:27][CH:28]1[NH:29][C:30](=[O:33])[O:31][CH2:32]1>>[c:2]1([N:29]2[CH:28]([CH3:27])[CH2:32][O:31][C:30]2=[O:33])[cH:3][c:4]([F:26])[c:5]([C:9](=[O:10])[N:11]2[CH2:12][CH2:13][N:14]([c:17]3[n:18][cH:19][c:20]([CH:23]4[CH2:24][CH2:25]4)[cH:21][cH:22]3)[CH2:15][CH2:16]2)[c:6]([F:8])[cH:7]1

Participants

3

Reactant 2

HCID 98554554-Methyl-1,3-oxazolidin-2-oneHCID 58484548(4-Bromo-2,6-difluorophenyl)[4-(5-cyclopropylpyridin-2-yl)piperazin-1-yl]methanone

Product 1

HCID 673808593-[4-[4-(5-Cyclopropyl-2-pyridinyl)piperazine-1-carbonyl]-3,5-difluorophenyl]-4-methyl-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-71cb6dd8d3924e269a47088801ad4241
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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