Sulfuryl chloride → 5-chloro-3-(2-methoxyphenyl)-1-{[4-methoxy-2-(trifluoromethoxy)phenyl]sulfonyl}-3-[2-oxo-2-(4-pyridin-4-yl piperidin-1-yl)ethyl]-1,3-dihydro-2H-indol-2-one
Reaction equation
[CH3:40][O:41][c:42]1[cH:43][c:44]([O:48][C:49]([F:50])([F:51])[F:52])[cH:45][cH:46][cH:47]1.[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[NH:7][C:6](=[O:11])[C:5]2([CH2:12][C:13]([N:14]1[CH2:15][CH2:16][CH:17]([c:20]2[cH:21][cH:22][n:23][cH:24][cH:25]2)[CH2:18][CH2:19]1)=[O:26])[c:27]1[c:28]([O:33][CH3:34])[cH:29][cH:30][cH:31][cH:32]1.[S:35](=[O:36])(=[O:37])([Cl:38])[Cl:39]>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([S:35](=[O:36])(=[O:37])[c:45]1[c:44]([O:48][C:49]([F:50])([F:51])[F:52])[cH:43][c:42]([O:41][CH3:40])[cH:47][cH:46]1)[C:6](=[O:11])[C:5]2([CH2:12][C:13]([N:14]1[CH2:15][CH2:16][CH:17]([c:20]2[cH:21][cH:22][n:23][cH:24][cH:25]2)[CH2:18][CH2:19]1)=[O:26])[c:27]1[c:28]([O:33][CH3:34])[cH:29][cH:30][cH:31][cH:32]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-ccf6b1a7ee8040cbae03fda0bff7b5dd
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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