Benzo-1,3-dioxole-5-methylamine → N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(2,6-difluorophenyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

HRID 948160Notes

Reaction equation

HRID 948160 reaction equation
[CH2:1]([O:2][C:4](=[O:5])[c:6]1[n:7][c:8](-[c:15]2[c:16]([F:22])[cH:17][cH:18][cH:19][c:20]2[F:21])[n:9]([CH3:14])[c:10](=[O:13])[c:11]1[OH:12])[CH3:3].[CH2:23]([c:24]1[cH:25][c:26]2[c:30]([cH:31][cH:32]1)[O:29][CH2:28][O:27]2)[NH2:33]>>[C:4](=[O:5])([c:6]1[n:7][c:8](-[c:15]2[c:16]([F:22])[cH:17][cH:18][cH:19][c:20]2[F:21])[n:9]([CH3:14])[c:10](=[O:13])[c:11]1[OH:12])[NH:33][CH2:23][c:24]1[cH:25][c:26]2[c:30]([cH:31][cH:32]1)[O:29][CH2:28][O:27]2

Participants

3

Reactant 2

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 546914342-(2,6-Difluoro-phenyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester

Product 1

HCID 54687117N-(benzo[d][1,3]dioxol-5-ylmethyl)-2-(2,6-difluorophenyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydropyrimidine-4-carboxamide

Sources & evidence

ORD record
ord-91693a0d854e4963b0b89d8cf38af4ae
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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