5-((Tert-butoxycarbonyl)amino)-2-(2,6-difluorophenyl)thiazole-4-carboxylic acid → tert-butyl 2-(2,6-difluorophenyl)-4-(1-ethyl-5-(4-(2,2,2-trifluoroacetamido)azepan-1-yl)-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate
Reaction equation
[C:25]([CH3:26])([CH3:27])([CH3:28])[O:29][C:30](=[O:31])[NH:32][c:33]1[c:34]([C:46](=[O:47])[OH:48])[n:35][c:36](-[c:38]2[c:39]([F:45])[cH:40][cH:41][cH:42][c:43]2[F:44])[s:37]1.[CH2:1]([CH3:2])[n:3]1[n:4][cH:5][c:6]([N+:22]([O-:23])=[O:24])[c:7]1[N:8]1[CH2:9][CH2:10][CH:11]([NH:15][C:16]([C:17]([F:18])([F:19])[F:20])=[O:21])[CH2:12][CH2:13][CH2:14]1>>[CH2:1]([CH3:2])[n:3]1[n:4][cH:5][c:6]([NH:22][C:46]([c:34]2[c:33]([NH:32][C:30]([O:29][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:31])[s:37][c:36](-[c:38]3[c:39]([F:45])[cH:40][cH:41][cH:42][c:43]3[F:44])[n:35]2)=[O:47])[c:7]1[N:8]1[CH2:9][CH2:10][CH:11]([NH:15][C:16]([C:17]([F:18])([F:19])[F:20])=[O:21])[CH2:12][CH2:13][CH2:14]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-39c31e20c0384090b7b48d512b876272
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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