1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-iodo-3-hydroxy-3-(2-chlorophenyl)oxindole → (+)-1-(2-Diethylaminoethyl)-4-trifluoromethyl-6-[4-(N-hydroxyethylcarbamoyl)-1-butynyl]-3-hydroxy-3-(2-chlorophenyl)oxindole
Reaction equation
[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:28])[C:8]([c:20]2[c:21]([Cl:26])[cH:22][cH:23][cH:24][cH:25]2)([OH:27])[c:9]2[c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]([I:15])[cH:13][c:14]21)[CH2:29][CH3:30].[OH:31][CH2:32][CH2:33][NH:34][C:35]([CH2:36][CH2:37][C:38]#[CH:39])=[O:40]>>[CH2:1]([CH3:2])[N:3]([CH2:4][CH2:5][N:6]1[C:7](=[O:28])[C:8]([c:20]2[c:21]([Cl:26])[cH:22][cH:23][cH:24][cH:25]2)([OH:27])[c:9]2[c:10]([C:16]([F:17])([F:18])[F:19])[cH:11][c:12]([C:39]#[C:38][CH2:37][CH2:36][C:35]([NH:34][CH2:33][CH2:32][OH:31])=[O:40])[cH:13][c:14]21)[CH2:29][CH3:30]Participants
3
Sources & evidence
- ORD record
- ord-08b0e97afb2f40c191bf5e5c3d7b8c36
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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