Diethyl 2-[[4-(methylamino)benzoyl]amino]pentanedioate → diethyl 2-[[4-[[3-(2,2-dimethylpropanoyloxymethyl)-4-oxoquinazolin-6-yl]methyl-methylamino]benzoyl]amino]pentanedioate
Reaction equation
[CH3:1][NH:2][c:3]1[cH:4][cH:5][c:6]([C:7]([NH:8][CH:9]([C:10]([O:11][CH2:12][CH3:13])=[O:14])[CH2:15][CH2:16][C:17]([O:18][CH2:19][CH3:20])=[O:21])=[O:22])[cH:23][cH:24]1.[O:25]=[c:26]1[n:27]([CH2:63][O:64][C:65]([C:66]([CH3:67])([CH3:68])[CH3:69])=[O:70])[cH:28][n:29][c:30]2[cH:31][cH:32][c:33]([CH2:36][N:37]([c:38]3[cH:39][cH:40][c:41]([C:42](=[O:43])[NH:44][CH:45]([CH2:46][CH2:47][C:48](=[O:49])[O:50][CH2:51][CH3:52])[C:53](=[O:54])[O:55][CH2:56][CH3:57])[cH:58][cH:59]3)[CH2:60][C:61]#[CH:62])[cH:34][c:35]12>>[O:25]=[c:26]1[n:27]([CH2:63][O:64][C:65]([C:66]([CH3:67])([CH3:68])[CH3:69])=[O:70])[cH:28][n:29][c:30]2[cH:31][cH:32][c:33]([CH2:36][N:37]([c:38]3[cH:39][cH:40][c:41]([C:42](=[O:43])[NH:44][CH:45]([CH2:46][CH2:47][C:48](=[O:49])[O:50][CH2:51][CH3:52])[C:53](=[O:54])[O:55][CH2:56][CH3:57])[cH:58][cH:59]3)[CH3:60])[cH:34][c:35]12Participants
3
Sources & evidence
- ORD record
- ord-af2d0c16fdac4ed3b63d07299cf69701
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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