N-{3-[5-(2-chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-3-fluorobenzenesulfonamide → N-{3-[2-(1,1-dimethylethyl)-5-(2-methyl-4-pyrimidinyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}-3-fluorobenzenesulfonamide
Reaction equation
[CH3:36][Zn:37][CH3:38].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:35])[c:19]([NH:24][S:25](=[O:26])(=[O:27])[c:28]4[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]4)[cH:20][cH:21][c:22]3[F:23])[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1>>[c:2]1([CH3:36])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:17]3[c:18]([F:35])[c:19]([NH:24][S:25](=[O:26])(=[O:27])[c:28]4[cH:29][c:30]([F:34])[cH:31][cH:32][cH:33]4)[cH:20][cH:21][c:22]3[F:23])[n:10][c:11]([C:13]([CH3:14])([CH3:15])[CH3:16])[s:12]2)[n:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-44962f58c3e94357a129186b51fb0359
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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