Hexamethylphosphoramide → Methyl 2-(cyanomethyl)-5-oxocyclopentane-1-carboxylate

HRID 949217Notes

Reaction equation

HRID 949217 reaction equation
[CH3:15][N:16]([CH3:17])[P:18](=[O:19])([N:20]([CH3:21])[CH3:22])[N:23]([CH3:24])[CH3:25].[CH3:4][O:5][C:6](=[O:7])[C:8]12[C:9](=[O:14])[CH2:10][CH2:11][CH:12]1[CH2:13]2.[K:1][C:2]#[N:3]>>[C:2](#[N:3])[CH2:13][CH:12]1[CH:8]([C:6]([O:5][CH3:4])=[O:7])[C:9](=[O:14])[CH2:10][CH2:11]1

Participants

4

Reactant 3

HCID 12679HexamethylphosphoramideHCID 12881134Methyl 2-oxobicyclo[3.1.0]hexane-1-carboxylateHCID 178511842HCID 178511842, compound

Product 1

HCID 24977136Methyl 2-(cyanomethyl)-5-oxocyclopentane-1-carboxylate

Sources & evidence

ORD record
ord-58e0450fca064f6bb336d6ee08f5cd48
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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