2-(6-Chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl ester → 2-{6-[3-Formyl-5-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-3-methoxy-pyridazin-4-yl}-indole-1-carboxylic acid tert-butyl ester

HRID 949375Notes

Reaction equation

HRID 949375 reaction equation
[C:29]([CH3:30])([CH3:31])([CH3:32])[O:33][C:34](=[O:35])[n:36]1[c:37](-[c:45]2[c:46]([O:52][CH3:53])[n:47][n:48][c:49]([Cl:51])[cH:50]2)[cH:38][c:39]2[cH:40][cH:41][cH:42][cH:43][c:44]12.[CH3:1][O:2][c:3]1[c:4]([O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[c:5]([CH:6]=[O:7])[cH:8][c:9]([B:11]2[O:12][C:13]([CH3:14])([CH3:15])[C:16]([CH3:17])([CH3:18])[O:19]2)[cH:10]1>>[CH3:1][O:2][c:3]1[c:4]([O:20][CH2:21][O:22][CH2:23][CH2:24][Si:25]([CH3:26])([CH3:27])[CH3:28])[c:5]([CH:6]=[O:7])[cH:8][c:9](-[c:49]2[n:48][n:47][c:46]([O:52][CH3:53])[c:45](-[c:37]3[n:36]([C:34]([O:33][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:35])[c:44]4[c:39]([cH:38]3)[cH:40][cH:41][cH:42][cH:43]4)[cH:50]2)[cH:10]1

Participants

3

Reactant 2

HCID 866120482-(6-Chloro-3-methoxy-pyridazin-4-yl)-indole-1-carboxylic acid tert-butyl esterHCID 866120613-Methoxy-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2-(2-trimethylsilanyl-ethoxymethoxy)-benzaldehyde

Product 1

HCID 866120602-{6-[3-Formyl-5-methoxy-4-(2-trimethylsilanyl-ethoxymethoxy)-phenyl]-3-methoxy-pyridazin-4-yl}-indole-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-5cf6cde88a7343b2b6128271bdf9699f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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