5-Amino-3-tert-butyl-1-(2-methylpyridine-5-yl)pyrazole → 1-(3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea

HRID 949391Notes

Reaction equation

HRID 949391 reaction equation
[C:30]([CH3:31])([CH3:32])([CH3:33])[c:34]1[n:35][n:36](-[c:40]2[cH:41][n:42][c:43]([CH3:46])[cH:44][cH:45]2)[c:37]([NH2:39])[cH:38]1.[F:1][c:2]1[c:3]([NH:20][C:21]([O:22][c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)=[O:29])[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][cH:11][n:12][c:13]3[c:14]2[n:15][cH:16][c:17](=[O:19])[nH:18]3)[cH:7]1>>[F:1][c:2]1[c:3]([NH:20][C:21](=[O:29])[NH:39][c:37]2[n:36](-[c:40]3[cH:41][n:42][c:43]([CH3:46])[cH:44][cH:45]3)[n:35][c:34]([C:30]([CH3:31])([CH3:32])[CH3:33])[cH:38]2)[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][cH:11][n:12][c:13]3[c:14]2[n:15][cH:16][c:17](=[O:19])[nH:18]3)[cH:7]1

Participants

3

Reactant 2

HCID 114019745-Amino-3-tert-butyl-1-(2-methylpyridine-5-yl)pyrazoleHCID 59588837Phenyl 2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenylcarbamate

Product 1

HCID 595888601-(3-tert-butyl-1-(6-methylpyridin-3-yl)-1H-pyrazol-5-yl)-3-(2-fluoro-4-(3-oxo-3,4-dihydropyrido[3,2-b]pyrazin-8-yloxy)phenyl)urea

Sources & evidence

ORD record
ord-8260b9cf580f4194a7eede142ef2fe84
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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