2-Bromo-5-(trifluoromethyl)pyridine → 3-Chloro-1-(4-isopropoxyphenyl)-5-(5-trifluoromethylpyridin-2-yl)indole-2-carboxylic acid ethyl ester
Reaction equation
[Br:35][c:36]1[n:37][cH:38][c:39]([C:42]([F:43])([F:44])[F:45])[cH:40][cH:41]1.[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7](-[c:25]2[cH:26][cH:27][c:28]([O:31][CH:32]([CH3:33])[CH3:34])[cH:29][cH:30]2)[c:8]2[cH:9][cH:10][c:11]([B:16]3[O:17][C:18]([CH3:19])([CH3:20])[C:21]([CH3:22])([CH3:23])[O:24]3)[cH:12][c:13]2[c:14]1[Cl:15]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[n:7](-[c:25]2[cH:26][cH:27][c:28]([O:31][CH:32]([CH3:33])[CH3:34])[cH:29][cH:30]2)[c:8]2[cH:9][cH:10][c:11](-[c:36]3[n:37][cH:38][c:39]([C:42]([F:43])([F:44])[F:45])[cH:40][cH:41]3)[cH:12][c:13]2[c:14]1[Cl:15]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-0dabfd3fd9a14fdcbcf61b443b5ca183
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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