N-(2-hydroxyphenethyl)acetamide → tert-Butyl 3-{2-[2-(2-acetylaminoethyl)phenoxy]ethoxy}-4-{4-[3-(2-chlorophenoxy)propoxy]phenyl}piperidine-1-carboxylate
Reaction equation
[Cl:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:28][CH2:29][CH2:30][O:31][S:32]([c:33]4[cH:34][cH:35][c:36]([CH3:37])[cH:38][cH:39]4)(=[O:40])=[O:41])[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:42][cH:43][cH:44][cH:45]1.[OH:46][c:47]1[c:48]([CH2:53][CH2:54][NH:55][C:56]([CH3:57])=[O:58])[cH:49][cH:50][cH:51][cH:52]1>>[Cl:1][c:2]1[c:3]([O:4][CH2:5][CH2:6][CH2:7][O:8][c:9]2[cH:10][cH:11][c:12]([CH:15]3[CH:16]([O:28][CH2:29][CH2:30][O:31][c:47]4[c:48]([CH2:53][CH2:54][NH:55][C:56]([CH3:57])=[O:58])[cH:49][cH:50][cH:51][cH:52]4)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:42][cH:43][cH:44][cH:45]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-8957f9ef9e1443ecbf5194b2aafd147a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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