2-Amino-5-(2-fluorophenyl)thiophene-3-carboxamide → 5-(2-Fluorophenyl)-2-{[6-(1-hydroxyethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH:8]([CH3:9])[OH:10])[n:7]1.[NH2:11][c:12]1[s:13][c:14](-[c:20]2[c:21]([F:26])[cH:22][cH:23][cH:24][cH:25]2)[cH:15][c:16]1[C:17](=[O:18])[NH2:19]>>[c:2]1([NH:11][c:12]2[s:13][c:14](-[c:20]3[c:21]([F:26])[cH:22][cH:23][cH:24][cH:25]3)[cH:15][c:16]2[C:17](=[O:18])[NH2:19])[cH:3][cH:4][cH:5][c:6]([CH:8]([CH3:9])[OH:10])[n:7]1Participants
3
Sources & evidence
- ORD record
- ord-a9dbbb0d3ba34b75b49a2a9e73bd73f5
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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