6-(6-acetamidopyrimidin-4-yl)oxy-N-[4-fluoro-3-(trifluoromethyl)phenyl]isoquinoline-1-carboxamide → 6-(6-aminopyrimidin-4-yl)oxy-N-[4-fluoro-3-(trifluoromethyl)phenyl]isoquinoline-1-carboxamide
Reaction equation
[F:1][c:2]1[c:3]([C:32]([F:33])([F:34])[F:35])[cH:4][c:5]([NH:8][C:9](=[O:10])[c:11]2[n:12][cH:13][cH:14][c:15]3[cH:16][c:17]([O:21][c:22]4[n:23][cH:24][n:25][c:26]([NH:28][C:29](=[O:30])[CH3:31])[cH:27]4)[cH:18][cH:19][c:20]23)[cH:6][cH:7]1.[N:36]1([CH2:37][c:38]2[cH:39][cH:40][c:41]([NH:42][C:43]([c:44]3[c:45]4[c:46]([cH:47][c:48]([O:49][c:50]5[cH:51][c:52]([NH:53][C:54](=[O:55])[CH3:56])[n:57][cH:58][n:59]5)[cH:60][cH:61]4)[cH:62][cH:63][cH:64]3)=[O:65])[cH:66][c:67]2[C:68]([F:69])([F:70])[F:71])[CH2:72][CH2:73][NH:74][CH2:75][CH2:76]1>>[F:1][c:2]1[c:3]([C:32]([F:33])([F:34])[F:35])[cH:4][c:5]([NH:8][C:9](=[O:10])[c:11]2[n:12][cH:13][cH:14][c:15]3[cH:16][c:17]([O:21][c:22]4[n:23][cH:24][n:25][c:26]([NH2:28])[cH:27]4)[cH:18][cH:19][c:20]23)[cH:6][cH:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-8007c46f4af9474fa281e0068abaa6ba
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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