Methanol → 7-Chloro-1-(2,3-dihydroxypropyl)-5-(o-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Reaction equation
[CH3:27][OH:28].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:26]1)[C:7]([c:19]1[c:20]([F:25])[cH:21][cH:22][cH:23][cH:24]1)=[N+:8]([O-:18])[CH2:9][C:10](=[O:17])[N:11]2[CH2:12][CH:13]([CH2:14][OH:15])[OH:16]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:26]1)[C:7]([c:19]1[c:20]([F:25])[cH:21][cH:22][cH:23][cH:24]1)=[N:8][CH2:9][C:10](=[O:17])[N:11]2[CH2:12][CH:13]([CH2:14][OH:15])[OH:16]Participants
3
Sources & evidence
- ORD record
- ord-335f217cc0d54761a11c2d65dd07bd5d
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…