N-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]methanesulfonamide → N-[2-(3-amino-7-bromoquinolin-4-ylamino)ethyl]methanesulfonamide

Participants

Reaction Steps

An 8 L stainless steel Parr vessel was charged with N-[2-(7-bromo-3-nitroquinolin-4-ylamino)ethyl]methanesulfonamide (61 g), 5% Pt/C catalyst (6.0 g) and acetonitrile (3 L). The vessel was evacuated, filled with hydrogen (45 psi, 3.1×105 Pa), and shaken at ambient temperature overnight. The reaction mixture was filtered through CELITE filter agent and concentrated under reduced pressure to provide N-[2-(3-amino-7-bromoquinolin-4-ylamino)ethyl]methanesulfonamide.

Provenance & Evidence