Ethanol → 4-Chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine

HRID 950127Notes

Reaction equation

HRID 950127 reaction equation
[C:34](=[O:35])([OH:36])[O-:37].[CH3:27][c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1.[CH3:40][CH2:41][OH:42].[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]([CH3:13])[CH3:14])[cH:9][c:10]2[I:11].[N+:15](=[O:16])([O-:17])[c:18]1[cH:19][cH:20][c:21]([B:24]([OH:25])[OH:26])[cH:22][cH:23]1.[Na+:38].[OH2:39]>>[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][n:7]1)[n:8]([CH:12]([CH3:13])[CH3:14])[cH:9][c:10]2-[c:21]1[cH:20][cH:19][c:18]([N+:15](=[O:16])[O-:17])[cH:23][cH:22]1

Participants

8

Reactant 7

HCID 702EthanolHCID 769Bicarbonate IonHCID 923Sodium ionHCID 962WaterHCID 1140TolueneHCID 27735524-Nitrophenylboronic acidHCID 195974264-Chloro-5-iodo-7-(propan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine

Product 1

HCID 195974814-Chloro-7-isopropyl-5-(4-nitrophenyl)pyrrolo[2,3-d]pyrimidine

Sources & evidence

ORD record
ord-fbeb3069ab22480b999bae164e5ed516
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…