Dichloromethane → 2-{4-[2-(Trifluoromethyl)phenoxy]piperidin-1-yl}-1,3-thiazole-5-carbonitrile
Reaction equation
[Cl:26][CH2:27][Cl:28].[F:1][C:2]([c:3]1[c:4]([O:5][CH:6]2[CH2:7][CH2:8][N:9]([c:12]3[s:13][c:14]([C:17](=[O:18])[NH2:19])[cH:15][n:16]3)[CH2:10][CH2:11]2)[cH:20][cH:21][cH:22][cH:23]1)([F:24])[F:25]>>[F:1][C:2]([c:3]1[c:4]([O:5][CH:6]2[CH2:7][CH2:8][N:9]([c:12]3[s:13][c:14]([C:17]#[N:19])[cH:15][n:16]3)[CH2:10][CH2:11]2)[cH:20][cH:21][cH:22][cH:23]1)([F:24])[F:25]Participants
3
Sources & evidence
- ORD record
- ord-a5930cec69104139b7b775e2e04a6397
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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