Acetic Acid → 3-(4-Chloro-2-fluoro-5-sulfanylphenyl)-1-methyl-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

HRID 950313Notes

Reaction equation

HRID 950313 reaction equation
[CH3:27][C:28](=[O:29])[OH:30].[Cl:1][c:2]1[c:3]([S:22]([Cl:23])(=[O:24])=[O:25])[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1.[OH2:26].[Zn:31]>>[Cl:1][c:2]1[c:3]([SH:22])[cH:4][c:5](-[n:9]2[c:10](=[O:21])[n:11]([CH3:20])[c:12]([C:16]([F:17])([F:18])[F:19])[cH:13][c:14]2=[O:15])[c:6]([F:8])[cH:7]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 23994ZincHCID 153345352-Chloro-4-fluoro-5-[3-methyl-2,6-dioxo-4-(trifluoromethyl)-1,2,3,6-tetrahydropyrimidin-1-yl]benzenesulfonyl chloride

Product 1

HCID 186192703-(4-Chloro-2-fluoro-5-sulfanylphenyl)-1-methyl-6-(trifluoromethyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione

Sources & evidence

ORD record
ord-cc4766d27c864a388b7f120f1d3032f0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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