Dichloromethane → tert-Butyl4-hydroxy-4-[4-(trifluoromethyl)pyridin-2-yl]piperidine-1-carboxylate
Reaction equation
[Br:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1.[CH2:12]([Li:13])[CH2:14][CH2:15][CH3:16].[CH2:31]([Cl:32])[Cl:33].[O:17]=[C:18]1[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]1>>[c:2]1([C:18]2([OH:17])[CH2:19][CH2:20][N:21]([C:24](=[O:25])[O:26][C:27]([CH3:28])([CH3:29])[CH3:30])[CH2:22][CH2:23]2)[n:3][cH:4][cH:5][c:6]([C:8]([F:9])([F:10])[F:11])[cH:7]1Participants
5
Sources & evidence
- ORD record
- ord-32590230885d4632a7c057542ec5fc6c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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