3-Fluoro-5-iodocinnamic Acid Methyl Ester → Tert-butyl 2-[[5-[3-fluoro-5-(3-methoxy-3-oxoprop-1-enyl)phenyl]-3-pyridinyl]oxymethyl]azetidine-1-carboxylate
Reaction equation
[C:15]([CH3:16])([CH3:17])([CH3:18])[O:19][C:20](=[O:21])[N:22]1[CH:23]([CH2:26][O:27][c:28]2[cH:29][n:30][cH:31][c:32]([Sn:34]([CH3:35])([CH3:36])[CH3:37])[cH:33]2)[CH2:24][CH2:25]1.[C:38]([O:39][C:40]([N:41]1[CH2:42][CH2:43][CH:44]1[CH2:45][O:46][c:47]1[cH:48][c:49](-[c:50]2[cH:51][c:52]([CH2:53][CH2:54][CH2:55][OH:56])[cH:57][cH:58][cH:59]2)[cH:60][n:61][cH:62]1)=[O:63])([CH3:64])([CH3:65])[CH3:66].[CH3:1][O:2][C:3]([CH:4]=[CH:5][c:6]1[cH:7][c:8]([F:13])[cH:9][c:10]([I:12])[cH:11]1)=[O:14]>>[CH3:1][O:2][C:3]([CH:4]=[CH:5][c:6]1[cH:7][c:8]([F:13])[cH:9][c:10](-[c:32]2[cH:31][n:30][cH:29][c:28]([O:27][CH2:26][CH:23]3[N:22]([C:20]([O:19][C:15]([CH3:16])([CH3:17])[CH3:18])=[O:21])[CH2:25][CH2:24]3)[cH:33]2)[cH:11]1)=[O:14]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-78aa1501fbf94eb18c2eddf2a6302ee4
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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