Methanesulfonyl chloride → [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)thiazol-5-yl]-(3-fluoro-4-methoxy-phenyl)methanone
Reaction equation
[CH3:25][S:26]([Cl:27])(=[O:28])=[O:29].[NH2:1][c:2]1[n:3][c:4]([NH:18][CH:19]2[CH2:20][CH2:21][NH:22][CH2:23][CH2:24]2)[s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][c:11]([F:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]1>>[NH2:1][c:2]1[n:3][c:4]([NH:18][CH:19]2[CH2:20][CH2:21][N:22]([S:26]([CH3:25])(=[O:28])=[O:29])[CH2:23][CH2:24]2)[s:5][c:6]1[C:7](=[O:8])[c:9]1[cH:10][c:11]([F:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]1Participants
3
Sources & evidence
- ORD record
- ord-463946b270374de88300e8123aaa814d
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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