1H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)- → 4-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

HRID 950670Notes

Reaction equation

HRID 950670 reaction equation
[Br:28][CH2:29][CH2:30][N:31]1[C:32](=[O:41])[c:33]2[c:34]([cH:37][cH:38][cH:39][cH:40]2)[C:35]1=[O:36].[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[CH:6]1[C:7](=[O:27])[c:8]2[c:9]([cH:23][cH:24][cH:25][cH:26]2)[N:10]([S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[CH2:11][CH2:12]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[C:6]1([CH2:29][CH2:30][N:31]2[C:32](=[O:41])[c:33]3[c:34]([cH:37][cH:38][cH:39][cH:40]3)[C:35]2=[O:36])[C:7](=[O:27])[c:8]2[c:9]([cH:23][cH:24][cH:25][cH:26]2)[N:10]([S:13](=[O:14])(=[O:15])[c:16]2[cH:17][cH:18][c:19]([CH3:22])[cH:20][cH:21]2)[CH2:11][CH2:12]1

Participants

3

Reactant 2

HCID 113251H-Isoindole-1,3(2H)-dione, 2-(2-bromoethyl)-HCID 12435934Ethyl 5-oxo-1-tosyl-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylate

Product 1

HCID 595505834-[2-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-ethyl]-5-oxo-1-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-1H-benzo[b]azepine-4-carboxylic acid ethyl ester

Sources & evidence

ORD record
ord-cc243effc68049a18037efa6d4a654d7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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