(Pyrimidin-5-yl)boronic acid → 1-(3,4-Difluoro-5-methoxyphenyl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]2([c:19]3[cH:20][c:21]([F:28])[c:22]([F:27])[c:23]([O:25][CH3:26])[cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1.[n:29]1[cH:30][n:31][cH:32][c:33]([B:35]([OH:36])[OH:37])[cH:34]1>>[c:2]1(-[c:33]2[cH:32][n:31][cH:30][n:29][cH:34]2)[cH:3][c:4]([C:8]2([c:19]3[cH:20][c:21]([F:28])[c:22]([F:27])[c:23]([O:25][CH3:26])[cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-f7ff6d9b9fb54e08a3565904954f08ae
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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