3-Pyridinemethanamine → 3-methyl-5-(1-(4-(methylsulfonyl)benzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiophene-2-carboxamide

HRID 950879Notes

Reaction equation

HRID 950879 reaction equation
[CH3:24][c:25]1[c:26]([C:47](=[O:48])[OH:49])[s:27][c:28](-[n:30]2[cH:31][n:32][n:33]([CH2:36][c:37]3[cH:38][cH:39][c:40]([S:43](=[O:44])(=[O:45])[CH3:46])[cH:41][cH:42]3)[c:34]2=[O:35])[cH:29]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][n:7]2[c:8](=[O:9])[n:10](-[c:11]3[s:12][c:13]([C:14]([OH:15])=[O:16])[c:17]([CH3:18])[cH:19]3)[cH:20][n:21]2)[cH:22][cH:23]1.[NH2:50][CH2:51][c:52]1[cH:53][n:54][cH:55][cH:56][cH:57]1>>[CH3:24][c:25]1[c:26]([C:47](=[O:49])[NH:50][CH2:51][c:52]2[cH:53][n:54][cH:55][cH:56][cH:57]2)[s:27][c:28](-[n:30]2[cH:31][n:32][n:33]([CH2:36][c:37]3[cH:38][cH:39][c:40]([S:43](=[O:44])(=[O:45])[CH3:46])[cH:41][cH:42]3)[c:34]2=[O:35])[cH:29]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 594811895-(1-(4-fluorobenzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-3-methylthiophene-2-carboxylic acidHCID 594812443-methyl-5-(1-(4-(methylsulfonyl)benzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)thiophene-2-carboxylic acid

Product 1

HCID 594812783-methyl-5-(1-(4-(methylsulfonyl)benzyl)-5-oxo-1H-1,2,4-triazol-4(5H)-yl)-N-(pyridin-3-ylmethyl)thiophene-2-carboxamide

Sources & evidence

ORD record
ord-e2453ab291df4c2a8e303972110824fe
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…