N3-Benzyl-2-chloronicotinamide → 4-(4-(3-(Benzylcarbamoyl)pyridin-2-ylamino)-2-fluorophenoxy)picolinamide
Reaction equation
[CH2:54]([c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1)[NH:61][C:62]([c:63]1[c:64]([Cl:69])[n:65][cH:66][cH:67][cH:68]1)=[O:70].[F:19][c:20]1[cH:21][c:22]([F:23])[cH:24][cH:25][c:26]1[NH:27][C:28]([c:29]1[cH:30][n:31][cH:32][cH:33][c:34]1[NH:35][c:36]1[cH:37][cH:38][c:39]([O:40][c:41]2[cH:42][c:43]([C:44]([NH2:45])=[O:46])[n:47][cH:48][cH:49]2)[c:50]([F:51])[cH:52]1)=[O:53].[NH2:1][c:2]1[cH:3][c:4]([F:18])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][cH:17]1>>[NH:1]([c:2]1[cH:3][c:4]([F:18])[c:5]([O:6][c:7]2[cH:8][c:9]([C:13](=[O:14])[NH2:15])[n:10][cH:11][cH:12]2)[cH:16][cH:17]1)[c:64]1[c:63]([C:62]([NH:61][CH2:54][c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)=[O:70])[cH:68][cH:67][cH:66][n:65]1Participants
4
Sources & evidence
- ORD record
- ord-e9e6288a8ebf40058a40e64c8a2ce37b
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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