Piperazin-2-one → 3-{3-(3-Chloro-5-fluorophenyl)-5-[(3-oxopiperazin-1-yl)carbonyl]furan-2-yl}benzenecarbonitrile
Reaction equation
[Cl:1][c:2]1[cH:3][c:4](-[c:5]2[cH:6][c:7]([C:8](=[O:9])[N:22]3[CH2:23][C:24](=[O:28])[NH:25][CH2:26][CH2:27]3)[o:10][c:11]2-[c:12]2[cH:13][cH:14][c:15]([F:16])[cH:17][cH:18]2)[cH:19][cH:20][cH:21]1.[Cl:29][c:30]1[cH:31][c:32](-[c:37]2[cH:38][c:39]([C:50](=[O:51])[OH:52])[o:40][c:41]2-[c:42]2[cH:43][c:44]([C:48]#[N:49])[cH:45][cH:46][cH:47]2)[cH:33][c:34]([F:36])[cH:35]1.[NH:53]1[CH2:54][CH2:55][NH:56][CH2:57][C:58]1=[O:59]>>[N:22]1([C:50]([c:39]2[cH:38][c:37](-[c:32]3[cH:31][c:30]([Cl:29])[cH:35][c:34]([F:36])[cH:33]3)[c:41](-[c:42]3[cH:43][c:44]([C:48]#[N:49])[cH:45][cH:46][cH:47]3)[o:40]2)=[O:51])[CH2:23][C:24](=[O:28])[NH:25][CH2:26][CH2:27]1Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-7e8480c2ccc746b4850ad96061e37a8c
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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