1-[4-[(4-Fluorophenyl)methyl]phenyl]piperazine → 1-[4-[(4-Fluorophenyl)methyl]phenyl]-4-[3-(4-fluorophenyl)prop-2-enyl]piperazine
Reaction equation
[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([N:15]3[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:6][cH:7]1.[F:21][c:22]1[cH:23][cH:24][c:25]([CH:26]=[CH:27][CH2:28][Br:29])[cH:30][cH:31]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][c:9]2[cH:10][cH:11][c:12]([N:15]3[CH2:16][CH2:17][N:18]([CH2:28][CH:27]=[CH:26][c:25]4[cH:24][cH:23][c:22]([F:21])[cH:31][cH:30]4)[CH2:19][CH2:20]3)[cH:13][cH:14]2)[cH:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-8d44028e54014545bfbf676ed0fe472c
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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