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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 951784Generated: October 30, 2026

Acetic Acid → 6-fluoro-3-[4-[4-[[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]methyl]phenyl]-5,5-dimethylfuran-2-ylidene]-1H-indol-2-one

https://huagongshe.com/reaction/951784

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetic AcidHCID 176—
ReactantBicarbonate IonHCID 769—
ReactantMethanolHCID 887—
ReactantSodium ionHCID 923—
ReactantWaterHCID 962—
ReactantDimethylformamideHCID 6228—
ReactantTetrahydrofuranHCID 8028—
Reactant1-[2-(2-Hydroxyethoxy)ethyl]piperazineHCID 139436—
ReactantCyano-borohydrideHCID 498716—
Reactant4-[5-(6-fluoro-2-oxo-1H-indol-3-ylidene)-2,2-dimethylfuran-3-yl]benzaldehydeHCID 72464764—
Product6-fluoro-3-[4-[4-[[4-[2-(2-hydroxyethoxy)ethyl]piperazin-1-yl]methyl]phenyl]-5,5-dimethylfuran-2-ylidene]-1H-indol-2-oneHCID 69409832—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-f882dba17cfa494b9e88b230bb319f38
Source noteValidation data from https://doi.org/10.1039/C8SC04228D