Water → 4-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine

HRID 951829Notes

Reaction equation

HRID 951829 reaction equation
[Cl:1][c:2]1[c:3](-[c:12]2[c:13]([N+:25]([O-:26])=[O:27])[c:14]([NH:18][CH:19]([CH2:20][CH3:21])[CH:22]3[CH2:23][CH2:24]3)[n:15][cH:16][cH:17]2)[cH:4][c:5]([F:11])[c:6]([N:8]([CH3:9])[CH3:10])[cH:7]1.[OH2:31].[Sn:28]([Cl:29])[Cl:30]>>[Cl:1][c:2]1[c:3](-[c:12]2[c:13]([NH2:25])[c:14]([NH:18][CH:19]([CH2:20][CH3:21])[CH:22]3[CH2:23][CH2:24]3)[n:15][cH:16][cH:17]2)[cH:4][c:5]([F:11])[c:6]([N:8]([CH3:9])[CH3:10])[cH:7]1

Participants

4

Reactant 3

HCID 962WaterHCID 24479Stannous ChlorideHCID 22052078[4-(2-Chloro-4-dimethylamino-5-fluoro-phenyl)-3-nitro-pyridin-2-yl]-(1-cyclopropyl-propyl)-amine

Product 1

HCID 696579484-(2-chloro-4-dimethylamino-5-fluoro-phenyl)-N2-(1-cyclopropyl-propyl)-pyridine-2,3-diamine

Sources & evidence

ORD record
ord-35a508056e984e45ab74eb086e73c6e3
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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