Bromide ion → 2-Cyclobutyl-4-trifluoromethyl-benzoic acid

HRID 952204Notes

Reaction equation

HRID 952204 reaction equation
[Br-:32].[CH3:17][O:18][C:19](=[O:20])[c:21]1[cH:22][cH:23][c:24]([C:25]([F:26])([F:27])[F:28])[cH:29][c:30]1[I:31].[CH:1]1([c:4]2[c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10][c:11]([C:13]([F:14])([F:15])[F:16])[cH:12]2)[CH2:2][CH2:3]1.[CH:33]1([Zn+:34])[CH2:35][CH2:36][CH2:37]1>>[CH:1]1([c:4]2[c:5]([C:6](=[O:7])[OH:8])[cH:9][cH:10][c:11]([C:13]([F:14])([F:15])[F:16])[cH:12]2)[CH2:3][CH2:2][CH2:17]1

Participants

5

Reactant 4

HCID 259Bromide ionHCID 59438424Methyl 2-iodo-4-(trifluoromethyl)benzoateHCID 594384852-Cyclopropyl-4-(trifluoromethyl)benzoic acidHCID 178528062HCID 178528062, compound

Product 1

HCID 594384322-Cyclobutyl-4-trifluoromethyl-benzoic acid

Sources & evidence

ORD record
ord-e4bde431b7da487d84b22924423f3eeb
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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