Water → [2-(4-Methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine

HRID 952426Notes

Reaction equation

HRID 952426 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH3:40][O:41][CH2:42][CH2:43][O:44][CH3:45].[Cl:1][c:2]1[cH:3][c:4]([NH:10][CH2:11][CH2:12][c:13]2[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]2)[n:5][c:6]([O:8][CH3:9])[n:7]1.[Cs+:38].[Cs+:39].[OH2:46].[n:21]1[cH:22][cH:23][cH:24][c:25]2[cH:26][c:27]([B:31]([OH:32])[OH:33])[cH:28][cH:29][c:30]12>>[c:2]1(-[c:27]2[cH:26][c:25]3[cH:24][cH:23][cH:22][n:21][c:30]3[cH:29][cH:28]2)[cH:3][c:4]([NH:10][CH2:11][CH2:12][c:13]2[cH:14][cH:15][c:16]([O:19][CH3:20])[cH:17][cH:18]2)[n:5][c:6]([O:8][CH3:9])[n:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 80711,2-DimethoxyethaneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 4192671Quinolin-6-ylboronic Acid (contains varying amounts of Anhydride)HCID 57636025(6-Chloro-2-methoxy-pyrimidin-4-yl)-[2-(4-methoxyphenyl)-ethyl]amine

Product 1

HCID 11523888[2-(4-Methoxy-phenyl)-ethyl]-(2-methoxy-6-quinolin-6-yl-pyrimidin-4-yl)-amine

Sources & evidence

ORD record
ord-fdb1365630114a9e9af0b7b454144545
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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