3-Fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinic acid → Tert-butyl 4-(2,4-difluorophenyl)-4-((3-fluoro-4-(2-(4-methylpyridin-2-ylamino)thiazol-5-ylthio)picolinamido)methyl)piperidine-1-carboxylate
Reaction equation
[F:1][c:2]1[c:3]([C:22](=[O:23])[OH:24])[n:4][cH:5][cH:6][c:7]1[S:8][c:9]1[cH:10][n:11][c:12]([NH:14][c:15]2[n:16][cH:17][cH:18][c:19]([CH3:21])[cH:20]2)[s:13]1.[NH2:25][CH2:26][C:27]1([c:40]2[c:41]([F:47])[cH:42][c:43]([F:46])[cH:44][cH:45]2)[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]1>>[F:1][c:2]1[c:3]([C:22](=[O:24])[NH:25][CH2:26][C:27]2([c:40]3[c:41]([F:47])[cH:42][c:43]([F:46])[cH:44][cH:45]3)[CH2:28][CH2:29][N:30]([C:33](=[O:34])[O:35][C:36]([CH3:37])([CH3:38])[CH3:39])[CH2:31][CH2:32]2)[n:4][cH:5][cH:6][c:7]1[S:8][c:9]1[cH:10][n:11][c:12]([NH:14][c:15]2[n:16][cH:17][cH:18][c:19]([CH3:21])[cH:20]2)[s:13]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-bb3891e0bc0f48a39a855af33116e194
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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