2,4-Dimethoxypyrimidine-5-boronic acid pinacol ester → 1-((2-(2,4-dimethoxypyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylpiperidine-4-carboxamide

HRID 95278Notes

Reaction equation

HRID 95278 reaction equation
[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][c:12]2[cH:13][c:14]3[n:15][c:16]([Cl:27])[n:17][c:18]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[c:19]3[s:20]2)[CH2:9][CH2:10]1.[CH3:28][O:29][c:30]1[n:31][cH:32][c:33]([B:38]2[O:39][C:40]([CH3:41])([CH3:42])[C:43]([CH3:44])([CH3:45])[O:46]2)[c:34]([O:36][CH3:37])[n:35]1>>[CH3:1][NH:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][N:8]([CH2:11][c:12]2[cH:13][c:14]3[n:15][c:16](-[c:33]4[cH:32][n:31][c:30]([O:29][CH3:28])[n:35][c:34]4[O:36][CH3:37])[n:17][c:18]([N:21]4[CH2:22][CH2:23][O:24][CH2:25][CH2:26]4)[c:19]3[s:20]2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 162183882,4-Dimethoxypyrimidine-5-boronic acid pinacol esterHCID 574939941-(2-Chloro-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-ylmethyl)-piperidine-4-carboxylic acid methylamide

Product 1

HCID 582340721-((2-(2,4-dimethoxypyrimidin-5-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)-N-methylpiperidine-4-carboxamide

Sources & evidence

ORD record
ord-381d8bd487d149eb86699d67d90d0170
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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