Ethanol → 2-[[4-(2-Chloropyridine-3-carbonyl)phenyl]methylsulfanyl]-3,5-dimethylquinazolin-4-one

HRID 952908Notes

Reaction equation

HRID 952908 reaction equation
[CH3:1][n:2]1[c:3]([SH:14])[n:4][c:5]2[cH:6][cH:7][cH:8][c:9]([CH3:13])[c:10]2[c:11]1=[O:12].[CH3:34][CH2:35][OH:36].[Cl:17][c:18]1[c:19]([C:20](=[O:21])[c:22]2[cH:23][cH:24][c:25]([CH2:26][Br:27])[cH:28][cH:29]2)[cH:30][cH:31][cH:32][n:33]1.[Na+:16].[OH-:15]>>[CH3:1][n:2]1[c:3]([S:14][CH2:26][c:25]2[cH:24][cH:23][c:22]([C:20]([c:19]3[c:18]([Cl:17])[n:33][cH:32][cH:31][cH:30]3)=[O:21])[cH:29][cH:28]2)[n:4][c:5]2[cH:6][cH:7][cH:8][c:9]([CH3:13])[c:10]2[c:11]1=[O:12]

Participants

6

Reactant 5

HCID 702EthanolHCID 923Sodium ionHCID 961HydroxideHCID 18919028[4-(Bromomethyl)phenyl]-(2-chloro-3-pyridinyl)methanoneHCID 178424003HCID 178424003, compound

Product 1

HCID 189191112-[[4-(2-Chloropyridine-3-carbonyl)phenyl]methylsulfanyl]-3,5-dimethylquinazolin-4-one

Sources & evidence

ORD record
ord-3ead44ffcfa44394a082b8346fff2481
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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