Methanol → Tert-butyl 6-(4-amino-2-fluorophenoxy)pyrimidin-4-ylcarbamate

HRID 953187Notes

Reaction equation

HRID 953187 reaction equation
[CH3:28][OH:29].[F:1][c:2]1[c:3]([O:4][c:5]2[cH:6][c:7]([NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[n:8][cH:9][n:10]2)[cH:19][cH:20][c:21]([N+:23]([O-:24])=[O:25])[cH:22]1.[H:26][H:27]>>[F:1][c:2]1[c:3]([O:4][c:5]2[cH:6][c:7]([NH:11][C:12]([O:13][C:14]([CH3:15])([CH3:16])[CH3:17])=[O:18])[n:8][cH:9][n:10]2)[cH:19][cH:20][c:21]([NH2:23])[cH:22]1

Participants

4

Reactant 3

HCID 887MethanolHCID 59852921Tert-butyl 6-(2-fluoro-4-nitrophenoxy)pyrimidin-4-ylcarbamateHCID 178418361HCID 178418361, compound

Product 1

HCID 59853037Tert-butyl 6-(4-amino-2-fluorophenoxy)pyrimidin-4-ylcarbamate

Sources & evidence

ORD record
ord-3cc0bcca8e5e4a4a9039b30fbace1b7f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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