Acetone → (6-Allyloxy-7-methoxy-quinazolin4-yl)-(4-bromo-2-fluoro-phenyl)-amine

HRID 953672Notes

Reaction equation

HRID 953672 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:8][c:9]2[n:10][cH:11][n:12][c:13]3[cH:14][c:15]([O:20][CH3:21])[c:16]([OH:19])[cH:17][c:18]23)[cH:6][cH:7]1.[CH2:29]([CH:30]=[CH2:31])[Br:32].[CH3:33][C:34](=[O:35])[CH3:36].[K+:23].[K+:24].[O-:25][C:26]([O-:27])=[O:28]>>[Br:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:8][c:9]2[n:10][cH:11][n:12][c:13]3[cH:14][c:15]([O:20][CH3:21])[c:16]([O:19][CH2:31][CH:30]=[CH2:29])[cH:17][c:18]23)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 7841Allyl bromideHCID 19660Carbonate IonHCID 210983904-((4-Bromo-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol

Product 1

HCID 21098402(6-Allyloxy-7-methoxy-quinazolin4-yl)-(4-bromo-2-fluoro-phenyl)-amine

Sources & evidence

ORD record
ord-5b4b9213ca5b4fec9e38212acbe3171a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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