Dimethyl Sulfoxide → 2-Bromo-4-(4-chloro-phenyl)-nicotinic acid

HRID 95376Notes

Reaction equation

HRID 95376 reaction equation
[Br:1][c:2]1[c:3]([C:4](=[O:5])[O:6][CH3:7])[c:8](-[c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)[cH:9][cH:10][n:11]1.[CH3:19][S:20]([CH3:21])=[O:22].[Na+:24].[OH-:23].[OH2:25]>>[Br:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[c:8](-[c:12]2[cH:13][cH:14][c:15]([Cl:18])[cH:16][cH:17]2)[cH:9][cH:10][n:11]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 923Sodium ionHCID 961HydroxideHCID 962WaterHCID 200952582-Bromo-4-(4-chloro-phenyl)-nicotinic acid methyl ester

Product 1

HCID 157671372-Bromo-4-(4-chloro-phenyl)-nicotinic acid

Sources & evidence

ORD record
ord-838b549d2ee0401495ae66a4052f8af6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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