(Pyrimidin-5-yl)boronic acid → 4-Fluoro-1-(6-methoxy-5-(trifluoromethyl)pyridin-3-yl)-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine
Reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:8]2([c:19]3[cH:20][n:21][c:22]([O:29][CH3:30])[c:23]([C:25]([F:26])([F:27])[F:28])[cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1.[n:31]1[cH:32][n:33][cH:34][c:35]([B:37]([OH:38])[OH:39])[cH:36]1>>[c:2]1(-[c:35]2[cH:34][n:33][cH:32][n:31][cH:36]2)[cH:3][c:4]([C:8]2([c:19]3[cH:20][n:21][c:22]([O:29][CH3:30])[c:23]([C:25]([F:26])([F:27])[F:28])[cH:24]3)[N:9]=[C:10]([NH2:18])[c:11]3[c:12]([F:17])[cH:13][cH:14][cH:15][c:16]32)[cH:5][cH:6][cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-d7048b7deab4491683f02c81d8fb5167
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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