1,4-Dioxane → 4-benzyloxycarbonylamino-4methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-5'-carboxylic acid tert-butyl ester

HRID 953932Notes

Reaction equation

HRID 953932 reaction equation
[C:19]([CH3:20])([CH3:21])([CH3:22])[O:23][C:24]([c:25]1[cH:26][n:27][c:28]([F:31])[cH:29][cH:30]1)=[O:32].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([NH:10][C:11]1([CH3:17])[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1)=[O:18].[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([NH:10][C:11]1([CH3:17])[CH2:12][CH2:13][N:14]([c:28]2[n:27][cH:26][c:25]([C:24]([O:23][C:19]([CH3:20])([CH3:21])[CH3:22])=[O:32])[cH:30][cH:29]2)[CH2:15][CH2:16]1)=[O:18]

Participants

4

Reactant 3

HCID 312751,4-DioxaneHCID 23282901Benzyl (4-methylpiperidin-4-yl)carbamateHCID 66756622tert-Butyl 6-fluoropyridine-3-carboxylate

Product 1

HCID 667571374-benzyloxycarbonylamino-4methyl-3,4,5,6-tetrahydro-2H-(1,2')bipyridinyl-5'-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-77c3f5d870c140c681db0046cb0a66b0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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