Pyridine → 3-{[6-(acetylamino)pyridin-3-yl]ethynyl}-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trimethylsilyl)phenyl}benzamide
Reaction equation
[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([C:11]#[C:12][c:13]2[cH:14][c:15]([C:16](=[O:17])[OH:18])[cH:19][cH:20][c:21]2[CH3:22])[cH:9][n:10]1.[CH3:23][N:24]1[CH2:25][CH2:26][N:27]([CH2:30][c:31]2[c:32]([Si:38]([CH3:39])([CH3:40])[CH3:41])[cH:33][c:34]([NH2:35])[cH:36][cH:37]2)[CH2:28][CH2:29]1.[cH:42]1[cH:43][cH:44][n:45][cH:46][cH:47]1>>[C:1]([CH3:2])(=[O:3])[NH:4][c:5]1[cH:6][cH:7][c:8]([C:11]#[C:12][c:13]2[cH:14][c:15]([C:16](=[O:18])[NH:35][c:34]3[cH:33][c:32]([Si:38]([CH3:39])([CH3:40])[CH3:41])[c:31]([CH2:30][N:27]4[CH2:26][CH2:25][N:24]([CH3:23])[CH2:29][CH2:28]4)[cH:37][cH:36]3)[cH:19][cH:20][c:21]2[CH3:22])[cH:9][n:10]1Participants
4
Sources & evidence
- ORD record
- ord-175698a77b7d4ff294b39f6df8532cf7
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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