2H-1-Benzazepin-2-one, 8-amino-1-ethyl-1,3,4,5-tetrahydro- → 3-{3-[5-Chloro-2-(1-ethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-phenyl}-propionitrile

HRID 954163Notes

Reaction equation

HRID 954163 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:19])[c:6]([NH:8][c:9]2[cH:10][c:11]([CH2:15][CH2:16][C:17]#[N:18])[cH:12][cH:13][cH:14]2)[n:7]1.[NH2:20][c:21]1[cH:22][c:23]2[c:24]([cH:33][cH:34]1)[CH2:25][CH2:26][CH2:27][C:28](=[O:32])[N:29]2[CH2:30][CH3:31]>>[c:2]1([NH:20][c:21]2[cH:22][c:23]3[c:24]([cH:33][cH:34]2)[CH2:25][CH2:26][CH2:27][C:28](=[O:32])[N:29]3[CH2:30][CH3:31])[n:3][cH:4][c:5]([Cl:19])[c:6]([NH:8][c:9]2[cH:10][c:11]([CH2:15][CH2:16][C:17]#[N:18])[cH:12][cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 98991662H-1-Benzazepin-2-one, 8-amino-1-ethyl-1,3,4,5-tetrahydro-HCID 866339783-[3-(2,5-Dichloro-pyrimidin-4-ylamino)-phenyl]-propionitrile

Product 1

HCID 668300513-{3-[5-Chloro-2-(1-ethyl-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-8-ylamino)-pyrimidin-4-ylamino]-phenyl}-propionitrile

Sources & evidence

ORD record
ord-8f46a6f5b2594a4ca037e0dfb30c8d76
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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