Ethanol → Methylphenidate Hydrochloride Impurity 16

HRID 954342Notes

Reaction equation

HRID 954342 reaction equation
[CH3:34][CH2:35][OH:36].[S:1](=[O:2])(=[O:3])([OH:4])[OH:5].[c:22]1([CH3:33])[cH:23][cH:24][c:25]([S:28](=[O:29])(=[O:30])[NH:31][NH2:32])[cH:26][cH:27]1.[c:6]1([C:12]([C:13](=[O:14])[N:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[O:21])[cH:7][cH:8][cH:9][cH:10][cH:11]1>>[c:6]1([C:12]([C:13](=[O:14])[N:15]2[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]2)=[N:32][NH:31][S:28]([c:25]2[cH:24][cH:23][c:22]([CH3:33])[cH:27][cH:26]2)(=[O:29])=[O:30])[cH:7][cH:8][cH:9][cH:10][cH:11]1

Participants

5

Reactant 4

HCID 702EthanolHCID 1118Sulfuric AcidHCID 15303P-ToluenesulfonylhydrazideHCID 109659651-Phenyl-2-(piperidin-1-yl)ethane-1,2-dione

Product 1

HCID 85395106Methylphenidate Hydrochloride Impurity 16

Sources & evidence

ORD record
ord-73a184389776445a908738bb748d3129
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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