Water → 2-[(4-Ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl-4-fluoropyrrolidine-2-carbonitrile

HRID 954695Notes

Reaction equation

HRID 954695 reaction equation
[Br:22][CH2:23][C:24](=[O:25])[N:26]1[CH:27]([C:32]#[N:33])[CH2:28][CH:29]([F:31])[CH2:30]1.[CH3:35][C:36]#[N:37].[CH:15]([NH:16][CH:17]([CH3:18])[CH3:19])([CH3:20])[CH3:21].[NH2:1][C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2.[OH2:34]>>[NH:1]([C:2]12[CH2:3][CH2:4][C:5]([C:10](=[O:11])[O:12][CH2:13][CH3:14])([CH2:6][CH2:7]1)[CH2:8][CH2:9]2)[CH2:23][C:24](=[O:25])[N:26]1[CH:27]([C:32]#[N:33])[CH2:28][CH:29]([F:31])[CH2:30]1

Participants

6

Reactant 5

HCID 962WaterHCID 6342AcetonitrileHCID 7912DiisopropylamineHCID 23149693Ethyl 4-aminobicyclo[2.2.2]octane-1-carboxylateHCID 231496951-(2-Bromoacetyl)-4-fluoropyrrolidine-2-carbonitrile

Product 1

HCID 231496942-[(4-Ethoxycarbonylbicyclo[2.2.2]oct-1-yl)amino]acetyl-4-fluoropyrrolidine-2-carbonitrile

Sources & evidence

ORD record
ord-0d93757f93f74cfcaade238fe226f924
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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